Insect molting is elicited by a class of polyhydroxylated steroids, ecdysteroids, that originate in the prothoracic glands. Ecdysteroid synthesis in the prothoracic glands is controlled in large measure by a peptide hormone from the brain, prothoracicotropic hormone (PTTH), which exists in two forms and is released into the general circulation as a result of environmental and developmental cues. The means by which PTTH activates the prothoracic glands has been examined at the cellular level and the data reveal the involvement of (...) cAMP, calcium, calmodulin, cAMP‐dependent protein kinase and the ultimate phosphorylation of a 34 kDa protein tentatively identified as ribosomal protein S6. (shrink)

We describe here recent work on the molecular genetics of mitosis in the filamentous fungus Aspergillus nidulans. Aspergillus is one of three simple eukaryotes with powerful genetic systems that have been used to analyze mitosis. The modern molecular biological techniques available with this organism have made it possible to use mutations to identify genes and proteins that play an important role in mitosis. Three Aspergillus genes that affect mitosis are described. One gene, nimA, is specifically expressed late in the cell (...) cycle and codes for a putative protein kinase that induces mitosis, even in cells blocked in S‐phase. The second gene, bimG, codes for a putative phosphatase that interacts functionally with the nimA kinase. The third gene, bimE, codes for a protein that suppresses mitosis during interphase, apparently by keeping nimA turned off. None of these genes appear to be similar to any of the genes affecting mitosis that have been characterized in other eukaryotes, but rather appear to be elements of a system that prevents mitosis from occurring during interphase. (shrink)

Benedict Spinoza is feted as the philosopher par excellence of the popular democratic multitude by Antonio Negri and others. But Spinoza himself expresses a marked ambivalence about the multitude in brief asides, and as for his thoughts on what he calls “the rule of multitude,” that is, democracy, these exist only as meager fragments in his unfinished Tractatus Politicus or Political Treatise. This essay addresses the problem of Spinoza’s multitude. First, I reconstruct a vision of power that is found in (...) the Ethics but that tends to be overlooked in the scholarly literature: power is not just sheer efficacy or imposition of will, but rather involves a capacity for being-affected; I call this the conception of power as sensitivity. The second part of my argument shows how, given Spinoza’s emphatic political naturalism, the conception of power as sensitivity can be extended to his political philosophy to shed light on what Spinoza calls potentia multitudinis, or “the power of the multitude”—a term found solely in the Political Treatise and nowhere else in his oeuvre. This juxtaposition reveals significant qualifications to the liberatory potential of the multitude currently claimed in the scholarly literature. (shrink)

It has often been said that the Zhuangzi 莊子 advocates political abstention, and that its putative skepticism prevents it from contributing in any meaningful way to political thinking: at best the Zhuangzi espouses a sort of anarchism, at worst it is “the night in which all cows are black,” a stance that one scholar has charged is ultimately immoral. This article tracks possible political allusions within the text, and, by reading these against details of social, political, and historical context, sheds (...) light on another strand of the Zhuangzi—one that questions prevailing normative values because it is fiercely critical of scholarly complicity with violent imperial territorial consolidation. (shrink)

The recent ‘material turn’ focuses on materiality in two distinctive ways: one, by including nonhuman agencies, another, by mining indigenous knowledges for alternative conceptions of agency and human–thing relations. A troubling gap persists between the two endeavours. The gap insinuates an us–them dichotomy and, more importantly, curtails communication between radically different visions of thingly agency – thereby impeding the political drive of these conceptual enterprises. This article is an essay in cross-cultural transposition. Through a close reading of a story of (...) a useless tree in an ancient proto-Daoist text, Zhuangzi, the author shows how its fabulist and oneiric form illuminates a distinctive perspective on uselessness. Conversely, the trope of uselessness lets us begin from what she calls a ‘situated affectivity’ amidst more-than-human materialities. The article concludes with a brief comparison of three modalities of uselessness from different ‘cosmologies’ of thought – a foretaste of the potentials of cross-cosmological endeavours. (shrink)

There has been a long debate on whether demonstratives are directly referential as Kaplan originally argued, or indirectly referential like a definite description. I propose a new analysis of demonstratives that combines intuitions from both direct and indirect approaches. The demonstrative is analyzed as an indirectly referential expression with a binary maximality operator that takes two arguments, where the second argument can be a deictic pointing, an anaphoric index, or a relative clause. Direct reference is encoded not in the meaning (...) of the demonstrative but in the meaning contributed by the pointing gesture, thus capturing both direct and indirect uses. I further propose that some pronouns in English function as demonstratives, realizing the binary structure and competing with the demonstrative. The main advantages of this proposal include (a) deriving the distribution of pronominal and adnominal demonstratives systematically; (b) capturing the unique interaction that demonstratives have with a pointing gesture; and (c) locating English demonstratives against a larger, cross-linguistic picture. (shrink)

This exploratory qualitative study investigated how doctoral students reported their personal and professional interaction experiences that they believed might facilitate or impede their academic pursuits in biomedical research. We collected 19 in-depth interviews with doctoral students in biomedical research from eight universities, and we based our qualitative analytic approach on the work of Miles and Huberman. The results indicated that among different sources and types of interaction, academic and emotional interactions from family and teachers in various stages essentially affected students’ (...) persistence in the biomedical science field. In addition, co-mentorship among peers, departmental environment, and volunteer experiences were other essential factors. This study also found related experiences among women and underrepresented minority students that were important to their academic pursuit. (shrink)

THE following further instances and parallels, and additional usages, may supplement the colloquialisms, &c, in Plato's dialogues which were listed and studied in a former article. 1. Colloquialisms More examples and parallels for usages previously noted: Charm. 154 b 4, Crat. 418 b 8, Phaedo 92 d 4, Parm. 126 c 6, 127 b 1, Polit. 290 d 7, Laws 630 b 7.

'ground-breaking anthology... wide array of perspectives on WW1, from both sides of the fighting' -B. Adler, Choice 'a very fine anthology' -Times Literary SupplementThe First World War inspired a huge outpouring of writing that, until recently, was thought to be almost the exclusive preserve of men. Yet the war also acted as a catalyst which enabled women writers to find a literary and political voice. This anthology bears witness to the great variety and scope of women's writing about the war. (...) Covering the years 1914-1930, the book brings together little-known writing from across the world, drawing on a wide spectrum of genres from letters and diary entries to essays, novels, and short stories. Among the celebrated writers featured in this anthology are: Radclyffe Hall, Sylvia Pankhurst, Maud Gonne, Rebecca West, May Sinclair, Olive Schreiner, Colette, Vera Brittain, Gertrude Stein, Katherine Mansfield, HD, and Virginia Woolf. (shrink)

In L. Frank Baum's story, Ozma of Oz, which is a sequel to Baum's much more famous story, The Wonderful Wizard of Oz, Dorothy and her companion come upon a wound-down mechanical man bearing a label on which are printed the following words: Smith and Tinker's Patent Double-Action, Extra-Responsive, Thought-Creating Perfect-Talking MECHANICAL MAN Fitted with our Special Clock-Work Attachment Thinks, Speaks, Acts, and Does Everything but Live As Dorothy and her companion are made to discover when they wind (...) up this man, he is indeed capable of doing all the things of which his label boasts—acting, speaking and even thinking. But as Tik-Tok himself insists, and no one in the story casts doubt on the matter, he is not alive. (shrink)

In this brief but formidable monograph Dorothy Emmet presents a splendid account of causation woven around numerous contemporary discussions. The largest portion of this book is devoted to an analysis of the epistemological problems of describing events in terms of cause and effect. Here Emmet defines her position in relation to the views of Davidson, Mellor, Anscombe, O'Neill, Prichard, Hornsby and others. Her main task however is to "pass beyond the epistemology to a metaphysics underpinning it", and this she (...) achieves with admirable clarity in the remainder of the book. As far as the latter is concerned, Emmet's views are strongly influenced by her former teacher, A. N. Whitehead, but unlike the followers of his process thought dominant in America today, she is more sympathetic to his views of nature developed in his middle period rather than those largely developed in Process and Reality. Furthermore, Emmet is more concerned to develop a substantial metaphysical position of her own rather than simply to expound Whitehead's doctrines. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Introducing Christian Ethics by Samuel Wells and Ben Quash, and: Christian Ethics: An Introductory Reader ed. by Samuel WellsBradley B. BurroughsReview of Introducing Christian Ethics SAMUEL WELLS AND BEN QUASH Malden, MA: Wiley-Blackwell, 2010. 400 pp. $49.95Review of Christian Ethics: An Introductory Reader EDITED BY SAMUEL WELLS Malden, MA: Wiley-Blackwell, 2010. 360 pp. $51.95Whether in a semester-long course or a textbook, the task of introducing Christian ethics generally (...) requires one to choose between various competing priorities. Perhaps the most remarkable feature of Introducing Christian Ethics is that it eschews such choices. Instead of settling for an “either/or,” Samuel Wells and Ben Quash repeatedly push for “both/and.” Their introduction not only traces the historical development of Christian ethics, examining major historical thinkers and elucidating the larger arcs that connect them, but also treats the work of contemporary Christian ethicists. Moreover, on the one hand, the authors develop a typology of ethical thought that distinguishes various strands according to the audience to which ethical reflection is directed—universal ethics (which addresses all people), subversive ethics (which addresses the oppressed), and ecclesial ethics (which addresses Christians). On the other hand, the authors also show how notable representatives of these strands approach matters of contemporary ethical concern. To this, Wells adds a sourcebook that allows for readers to interact further with many of the thinkers treated in the introductory text as well as helps to shed further light upon these three strands of Christian ethics. The scope of the project represented by these two books is thus exceptionally ambitious: it strives to provide a comprehensive overview of the field and organize it according to an innovative typology.Introducing Christian Ethics proceeds in three parts. In part 1, Wells and Quash tell “the story of Christian ethics,” exploring the biblical, historical, and philosophical sources from which Christian ethics has most commonly drawn and offering brief depictions of a vast array of Christian thinkers, including Justin Martyr, Tertullian, Augustine, Thomas Aquinas, Martin Luther, John Calvin, Reinhold Niebuhr, and many others. Part 2, titled “The Questions Christian Ethics Asks,” lays out the threefold taxonomy of universal, subversive, and ecclesial ethics, illustrating each with reference to thinkers both historical and contemporary. Finally, part 3 turns to “the questions asked of Christian [End Page 233] ethics,” treating issues of “good order” (including the role of the state and the nature of justice), “good life” (economics, poverty, and work), “good relationships” (friendship, marriage, homosexuality), “good beginnings and endings” (contraception, abortion, euthanasia), and “good earth” (animals, crops ecology). For each of the issues treated in part 3, the authors offer an overview and an account of how thinkers from each of the strands of Christian ethics have addressed that topic.Wells and Quash bring an admirably broad view of the field to bear upon this project. Famous thinkers factor prominently. And yet the book also treats the work of those less likely to appear in introductory texts, such as Germain Grisez, John Mbiti, and Stephen Clark. Whether they are of the renowned or lesser-known, the sketches of thinkers that occur throughout the book are on the whole quite accurate. Although there are places where experts might wish to call out slight mischaracterizations, the renderings are precise enough to serve introductory readers. Wells and Quash’s broadness of vision also includes both Protestant and Roman Catholic thought. Whereas Introducing Christian Ethics focuses primarily upon papal encyclicals as exemplifying the latter, Wells’s introductory reader adds selections from Gustavo Gutiérrez, Margaret Farley, Dorothy Day, and others to help exemplify the complexity of Roman Catholic ethical reflection. Eastern Orthodoxy gets shorter shrift, an observation offered as a note to potential readers rather than a criticism.Even as its comprehensiveness equips Introducing Christian Ethics for use in a variety of ways and contexts, the quest for comprehensiveness appears to be at the heart of some of the book’s infelicities. Attempting to treat so many thinkers and concepts, it frequently moves at a brisk pace, touching upon complex phenomena and abruptly moving on. In many places, the questions the book answers for the entry-level readers at which it aims... (shrink)